What do the different symbols in 23andme raw data files mean?

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In summary, 23andme is a company that sequences your genome using a saliva sample and provides a raw data file containing SNPs. The file may contain some SNPs with a genotype of "--" which means it is unknown, and some SNPs with only one letter which means the genotype of one allele could not be determined. The test may also have some inaccuracies or unreadable positions, resulting in some SNPs not being reported or incorrect readings. Repeating the measurements multiple times may help to identify any incorrect readings.
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mycotheology
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For anyone that doesn't know, 23andme is a company that sequences your genome for you (you send them a saliva sample). It gives you a raw data file ful of SNPs. Heres an example of some SNPs from a raw data file:

rs3128126 1 962210 GG
rs2710875 1 977780 TT
rs2465136 1 990417 CT
rs2488991 1 994391 --
rs7526076 1 998395 AA
rs3934834 1 1005806 CC
rs3766192 1 1017197 CC
rs3766191 1 1017587 CC
rs9442372 1 1018704 AA
rs10907177 1 1021346 AA
rs3737728 1 1021415 AA
rs10907178 1 1021583 AA
rs11260588 1 1021658 GG
rs9442398 1 1021695 --


I have a few questions about this. Firstly, what does -- mean, does that mean the genotype of that SNP is unknown? Secondly, some SNPs only give one letter, what does that mean? Does that mean they could only determine the genotype of one of the alleles?
 
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The test cannot determine all SNPs with 100% accuracy. At some random positions the reading is incorrect or it is not readable at all. In the latter case the SNP is simply not reported. On the other hand, if a wrong reading has been made, you will never know it, unless you repeat the measurements several times.
 
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FAQ: What do the different symbols in 23andme raw data files mean?

What is 23andMe?

23andMe is a direct-to-consumer genetic testing company that provides individuals with information about their genetic ancestry, traits, and health conditions.

How does 23andMe test for genetic information?

23andMe uses a saliva sample provided by the individual to extract and analyze DNA. This DNA is then compared to a reference database to determine genetic markers and identify potential health risks.

What information can I expect to receive from my 23andMe results?

Your 23andMe results will include information about your genetic ancestry, such as your genetic makeup, geographic origins, and potential relatives. It will also provide information about your genetic traits, such as eye color and hair texture, and any potential health risks associated with your genetic makeup.

How accurate are 23andMe results?

23andMe's results are generally accurate, but it is important to remember that they are based on genetic markers and do not necessarily determine your actual health status. It is always recommended to consult with a healthcare professional for a medical diagnosis.

Can I share my 23andMe results with other people?

Yes, you can choose to share your 23andMe results with family and friends through the company's online platform. However, it is important to consider the potential privacy implications before sharing your genetic information.

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