Which Site Will Grignard Reagent Attack: Ketone or Alkene?

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In summary, a Grignard reagent is an organometallic compound used in organic synthesis reactions. It is prepared by reacting an alkyl or aryl halide with magnesium metal in anhydrous ether. When working with Grignard reagents, it is important to take precautions as they are highly reactive and sensitive to moisture and air. In industry, Grignard reagents are commonly used in the synthesis of complex organic molecules and in the production of polymers.
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Aryamaan Thakur
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What product will be formed when reacted with Phenylmagnesium Bromide if the competition is between a carbon-oxygen double bond and a carbon-carbon double bond(as shown in figure)?
This is the given reaction:https://www.physicsforums.com/attachments/1559750554233-png.244625/
244628


Where will the reaction take place - at ketone or at alkene? And why?
 
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This sounds like a homework problem. Please note that we don’t provide answers to homework problems here, and that you’re not likely to receive positive feedback unless you show at least an attempt at a solution.
 

FAQ: Which Site Will Grignard Reagent Attack: Ketone or Alkene?

What is a Grignard reagent and how is it used in reactions?

A Grignard reagent is a type of organometallic compound made from an alkyl or aryl halide and magnesium metal. It is commonly used in organic chemistry reactions to form carbon-carbon bonds by reacting with a variety of electrophiles.

What types of reactions can be performed with Grignard reagents?

Grignard reagents are versatile and can be used in a variety of reactions, including nucleophilic addition, nucleophilic substitution, and reduction reactions. They are also commonly used to synthesize alcohols, aldehydes, ketones, and carboxylic acids.

What are the key factors that affect the reactivity of Grignard reagents?

The reactivity of Grignard reagents is influenced by several factors, including the nature of the halide used to form the reagent, the solvent used, and the presence of any coordinating groups on the electrophile. Additionally, steric hindrance and the strength of the carbon-magnesium bond can also impact reactivity.

Can Grignard reagents react with any type of compound?

While Grignard reagents are highly reactive, they do have limitations in terms of the types of compounds they can react with. For example, they cannot react with compounds that contain acidic protons, such as alcohols, phenols, or carboxylic acids, as these will react with the reagent instead of the desired electrophile.

What precautions should be taken when working with Grignard reagents?

Grignard reagents are highly reactive and can be dangerous if not handled properly. It is important to work with them in a well-ventilated area, as they can release flammable hydrogen gas. They should also be kept away from moisture and air, as this can cause them to decompose. Additionally, protective gear, such as gloves and safety glasses, should be worn when handling Grignard reagents.

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