Thanks for the reply vanhees.
I don't think this is true. Using ##a_p(t)=U^\dagger (t, t_0)a_p U(t, t_0)##, ##(3)## can be written as $$\bra{\Omega}U^\dagger (t_f, t_0)a_{p_1} U(t_f, t_0)\cdots U^\dagger (t_f, t_0)a_{p_n}\underbrace{U(t_f, t_0) U^\dagger (t_i, t_0)}_{U(t_f, t_i)}a_{k_1}^\dagger...