- #1
v_phoenix
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Hello,
I've been given this problem involving allelic frequencies and I used the Hardy Weinberg's Law as an attempt to solve it
Homework Statement
In a sample of 35 people, 19 have specific smell hypersensitvity to asparagus. Calculate the frequency of the allele in this sample given that the trait is autosomal dominant.
The attempt at a solution
Here is my working...
I represented the autosomal dominant faulty gene by 'A' and the working copy of the gene by 'a'.
AA = ?
Aa = ?
aa = 16 <<< # genotype (aa): 35-19 = 16
Total 35
I knew that the frequency of non affected recessive individuals = 1/35
Hence q^2 = 1/35... thus q=0.169 (3dp)
Hence p = 1 - 0.169 = 0.831 (3dp)...it then follows p^2 = 0.691 (3dp)
So putting it all together i got... 2pq = 2 * 0.831 * 0.169 = 0.28059
So after that I thought we should multiply these frequencies by the 19 people before to calculate the individual genotype frequencies...
AA = 13 <<< (p^2*19)
Aa = 5 <<< (2pq*19)
aa = 16
Total = 34
But here my total adds up to only 34 people!
I'm not sure if I'm doing it right or I'm missing something...
Please help, any suggestions will be greatly appreciated!
v_phoenix
I've been given this problem involving allelic frequencies and I used the Hardy Weinberg's Law as an attempt to solve it
Homework Statement
In a sample of 35 people, 19 have specific smell hypersensitvity to asparagus. Calculate the frequency of the allele in this sample given that the trait is autosomal dominant.
The attempt at a solution
Here is my working...
I represented the autosomal dominant faulty gene by 'A' and the working copy of the gene by 'a'.
AA = ?
Aa = ?
aa = 16 <<< # genotype (aa): 35-19 = 16
Total 35
I knew that the frequency of non affected recessive individuals = 1/35
Hence q^2 = 1/35... thus q=0.169 (3dp)
Hence p = 1 - 0.169 = 0.831 (3dp)...it then follows p^2 = 0.691 (3dp)
So putting it all together i got... 2pq = 2 * 0.831 * 0.169 = 0.28059
So after that I thought we should multiply these frequencies by the 19 people before to calculate the individual genotype frequencies...
AA = 13 <<< (p^2*19)
Aa = 5 <<< (2pq*19)
aa = 16
Total = 34
But here my total adds up to only 34 people!
I'm not sure if I'm doing it right or I'm missing something...
Please help, any suggestions will be greatly appreciated!
v_phoenix