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djflush
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and what is the name of the Ca2+ binding protein that is believed to underlie Ca2+ regulation of transmitter release
Calmodulin is a calcium-binding protein that helps regulate the release of neurotransmitters in the brain. It is found in all eukaryotic cells and is particularly important in neurons.
Calmodulin binds to calcium ions and undergoes a conformational change, allowing it to interact with other proteins and regulate their activity. In the context of neurotransmitter release, Calmodulin binds to specific proteins involved in the process and helps facilitate the release of neurotransmitters.
Calmodulin acts as a key regulator in the process of neurotransmitter release. It helps mediate the influx of calcium ions into the presynaptic terminal, which triggers the release of neurotransmitters into the synapse. It also plays a role in the recycling of vesicles and the maintenance of synaptic plasticity.
Calmodulin is activated by binding to calcium ions. When there is a rise in intracellular calcium levels, Calmodulin undergoes a conformational change that allows it to bind to other proteins and regulate their activity.
If Calmodulin is dysfunctional or impaired, it can lead to disruptions in neurotransmitter release and affect various cellular processes. For example, mutations in the gene encoding Calmodulin have been linked to neurological disorders such as epilepsy and autism. Additionally, malfunction of Calmodulin has been implicated in age-related cognitive decline.