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I don't know much about brain chemistry, but I gather that oxygen flow has something to do with thought waves, and the clarity and exuberance of thought that sometimes comes after intensive exercise would seem to substantiate this idea. Also, high brow reading is itself giving the mind an exercise in complex formal relations, which would expand various neural networks over time. Thirdly, socialization/ argumentation with those who are smarter than you can only help. Anyone care to refute or add to these ideas?