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Same thing we do every night, Try to take over the world!
http://www.mult-sclerosis.org/news/Feb2001/MouseWithHumanBrainCells.html
http://www.mult-sclerosis.org/news/Feb2001/MouseWithHumanBrainCells.html
The question is a reference to the popular animated TV show "Pinky and the Brain" in which Brain, a genius mouse, constantly schemes to take over the world while his dim-witted sidekick Pinky asks this question every night.
Pinky is a loyal and enthusiastic follower of Brain and always wants to know what their plans are for the next night. He is also very forgetful and needs reminders of their plans.
This catchphrase has become iconic and is often used by fans of the show. It showcases the dynamic between the two main characters and highlights Brain's ambitious and often grandiose plans.
No, Brain always responds with "The same thing we do every night, Pinky - try to take over the world!" as it is his ultimate goal and obsession.
Some fans have theorized that this question and answer represent the never-ending cycle of trying and failing in life. No matter how many times Brain tries to take over the world, he ultimately fails and the cycle repeats itself.