- #1
icakeov
- 379
- 27
I've read in a few places that acetylation of histones creates transcription activation rather than repression (the common example being: H3K9).
What I am curious, with the absence of this acetylation (I'm guessing this would the process de-acetylation), do the genes that were previously acetylated actually stop expressing themselves?
If yes, would it be fair to say that this process is opposite from the classic methylation outcome, which represses by bonding, and activates by detaching.
I hope this made sense, still working on wrapping my head around some of these topics.
Any feedback really appreciated!
By the way, I think this paper touches on this and suggests that deacetylation directly creates chromosome condensation.
What I am curious, with the absence of this acetylation (I'm guessing this would the process de-acetylation), do the genes that were previously acetylated actually stop expressing themselves?
If yes, would it be fair to say that this process is opposite from the classic methylation outcome, which represses by bonding, and activates by detaching.
I hope this made sense, still working on wrapping my head around some of these topics.
Any feedback really appreciated!
By the way, I think this paper touches on this and suggests that deacetylation directly creates chromosome condensation.
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