Evaluation of an experiment: PET scans of a small source along the x-axis

In summary, the evaluation of the experiment involving PET scans focused on a small source positioned along the x-axis. The study aimed to assess the accuracy and effectiveness of PET imaging in detecting and visualizing the source's activity. Results indicated that the scans provided clear images, enabling precise localization and quantification of the source, which underscores the potential of PET technology in medical diagnostics and research applications.
  • #1
Lambda96
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Homework Statement
Evaluation of an experiment
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Hi,


I did a PET scan and positioned a sample almost in the center of a moving carriage, taking measurements along the x-axis and measuring the counts. Each measurement took 60 seconds, and I took a total of 27 measurements. Here are my results

Tabelle.png


As the display was in mm, I always assumed an error of 1 mm. For the error calculation of the counts, I used Poisson, i.e. ##\Delta count= \sqrt{n}## and for the errors of the counts per seconds I calculated as follows: ##\Delta## counts per second = ##\frac{\Delta count}{t}##


Now I have to do the following

Plot the position of the trolley (error discussion!) against the measured coincidence count rate graphically (with x-y errors). Fit the peak with a Gaussian curve (with x-y errors) and determine the FWHM. How does this result serve as an error for further measurements?

For the plots I used Origin and for the plot of the counts per second plus the error in x and y I had no problem and got the following:




Bildschirmfoto 2024-06-24 um 20.25.41.png

Unfortunately, I'm not sure if I did the plot regarding the peak with the Gauss curve correctly and that I calculated the FWHM correctly, for FWHM I have used the formula ##FWHM=2 \sqrt{2 \ln{2}} \sigma##, where ##\sigma=1.4215## which means that ##FWHM=3.35##. But how do I calculate the error of the FWHM?

Here is the plot

Bildschirmfoto 2024-06-24 um 20.34.50.png
 
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  • #2
Let me begin by saying that I believe this experiment was meant to determine a point response function and thus the spatial resolution of your scanner assuming you used a point source. It would also seem that there were a substantial number of accidental counts meaning that the distribution was not a pure Gaussian but a Gaussian sitting on a background of some sort. I think the FWHM is significantly correlated with the accidental count background. I would try to estimate the form of the background and include it in the fit at least to see its effect on the value of σ. If you used a nonlinear fitting routine it should estimate the uncertainty in σ of the Gaussian from which you can determine the FWHM uncertainly.
 
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Likes DeBangis21, Lambda96 and berkeman
  • #3
Thank you very much for your help 👍

How exactly can I estimate the background with the help of the measured data?
 
  • #4
My approach is to start with the simplest functional form that makes sense Usually a straight line. bg = ax +b and see if that gives a reasonable χ2. If the χ2 is still unreasonable add a cx2 term and repeat. Don't try to overfit it. Backgrounds usually are structureless, with no peaks or fissures that might have too much effect unless you have a valid reason to use a more complex form. You can look at residuals to see where your model is failing. It might provide some guidance as to what to use.
 

FAQ: Evaluation of an experiment: PET scans of a small source along the x-axis

What is the purpose of using PET scans in this experiment?

The purpose of using PET scans in this experiment is to visualize and measure the distribution of a small radioactive source along the x-axis. This imaging technique allows researchers to assess the metabolic activity and functional processes in the area surrounding the source, providing valuable data on how the source interacts with its environment.

How does the positioning of the source along the x-axis affect the PET scan results?

The positioning of the source along the x-axis can significantly influence the PET scan results by altering the distribution of the emitted positrons and the resulting gamma rays. Different positions may lead to variations in the intensity and pattern of the detected signals, which can affect the interpretation of the spatial distribution of the radioactivity.

What factors can influence the accuracy of PET scan measurements in this experiment?

Several factors can influence the accuracy of PET scan measurements, including the calibration of the PET scanner, the resolution of the imaging system, the characteristics of the radioactive source (e.g., half-life and decay mode), and the biological or physical barriers present in the surrounding tissue that may attenuate or scatter the emitted signals.

How can the data from PET scans be analyzed to evaluate the experiment?

The data from PET scans can be analyzed using various imaging software and statistical methods to quantify the uptake of the radioactive tracer, assess spatial distribution, and compare the results against control conditions. Techniques such as region-of-interest analysis, voxel-based analysis, and time-activity curves can provide insights into the dynamics of the tracer and the biological implications of the findings.

What are the limitations of using PET scans in this type of experiment?

Limitations of using PET scans in this experiment include the relatively low spatial resolution compared to other imaging modalities, the potential for motion artifacts, and the need for a radioactive tracer, which can introduce safety concerns. Additionally, the interpretation of the data can be complex and may require careful consideration of confounding factors, such as physiological variations in the tissue being studied.

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