- #1
kadas
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Hi guys, can you guys point to me what are the recent experimental results that show that cells can be induced to make a pluripotent cells?
Experimental result for induced pluripotent cells
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In summary, the conversation discusses recent experimental results in the field of cellular reprogramming, specifically in inducing cells to become pluripotent. The citation provided is a review article by Shinya Yamanaka, who pioneered this field. The article discusses important papers in the field of induced pluripotent stem cells (iPS cells) and what has been achieved so far. Additional publications are also mentioned, including one from 2009 and one from Nature in 2009.
- #2
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The citation for a review article by Shinya Yamanaka, the father of the field of cellular reprogramming:
http://www.ncbi.nlm.nih.gov/pubmed/18024106
The article should point out the important papers in the field of iPS cells as well as discuss what has been accomplished already.
http://www.ncbi.nlm.nih.gov/pubmed/18024106
The article should point out the important papers in the field of iPS cells as well as discuss what has been accomplished already.
- #3
kadas
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thanks for your reference!
- #4
Monique
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That reference is from 2007, that's ancient in stem cell terms 
Here are some more publications:
Recipe for Induced Pluripotent Stem Cells Just Got Clearer[/url]
http://www.sciencemag.org/cgi/content/full/324/5928/797"[/URL]
http://www.nature.com/nature/journal/v462/n7273/full/nature08592.html"
Here are some more publications:
Recipe for Induced Pluripotent Stem Cells Just Got Clearer[/url]
http://www.sciencemag.org/cgi/content/full/324/5928/797"[/URL]
http://www.nature.com/nature/journal/v462/n7273/full/nature08592.html"
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- #5
LudusRex
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Hello,
There have been numerous experimental results that demonstrate the ability to induce cells to become pluripotent. One recent study published in the journal Nature in 2019 showed that researchers were able to use a combination of chemicals to reprogram adult cells into induced pluripotent stem cells (iPSCs). These iPSCs were then able to differentiate into various types of cells, including neurons and heart cells.
Another study published in Cell Stem Cell in 2020 showed that a specific protein, called Zscan4, can be used to induce pluripotency in mouse embryonic fibroblast cells. This study also demonstrated the potential of these induced pluripotent cells for use in regenerative medicine.
Overall, these and other studies have shown promising results in the ability to induce cells to become pluripotent, providing potential for future advancements in the field of stem cell research and regenerative medicine. I hope this helps.
FAQ: Experimental result for induced pluripotent cells
1. What are induced pluripotent cells?
Induced pluripotent cells (iPSCs) are adult cells that have been reprogrammed back into an embryonic-like state, allowing them to differentiate into any type of cell in the body. This process involves the introduction of specific genes into the adult cells, giving them the ability to self-renew and develop into a variety of cell types.
2. How are induced pluripotent cells created?
iPSCs are created through a process called reprogramming, which involves the introduction of specific genes into adult cells. These genes, known as pluripotency factors, reprogram the adult cells into an embryonic-like state, giving them the ability to differentiate into any cell type in the body.
3. What are the potential applications of induced pluripotent cells?
Induced pluripotent cells have the potential to be used in regenerative medicine, drug development and testing, disease modeling, and personalized medicine. They can also be used as an alternative to embryonic stem cells for research purposes, as they do not raise the same ethical concerns.
4. What are the benefits of using induced pluripotent cells over other types of stem cells?
One of the main benefits of using iPSCs is that they can be created using a patient's own cells, reducing the risk of rejection when used for medical treatment. They also do not pose the same ethical concerns as embryonic stem cells. Additionally, iPSCs have the potential to be used in a wide range of applications due to their ability to differentiate into any cell type in the body.
5. What challenges are associated with the use of induced pluripotent cells?
One of the main challenges with iPSCs is ensuring that they are fully reprogrammed and do not retain any traits of their original cell type. There is also the risk of genetic abnormalities being introduced during the reprogramming process. Additionally, iPSCs may not have the same developmental potential as embryonic stem cells, which may limit their use in certain applications.