Exploring Regulation of HSP Gene Expression: Seeking Advice

[jhirlo]

I was trying to find something about regulation mechanisms for expression of HSP genes, but no luck.
Thing is I was thing about, maybe, possibility of thermo unstable repressor mechanism, but I don’t know how much that is possible.
Any comments or information would be great.

 

[iansmith]

Does this help.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=390654
http://www-ermm.cbcu.cam.ac.uk/01003568a.pdf
http://www.jbc.org/cgi/content/short/279/20/20672
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=3275876

 

[ravenprp]

Regulation of HSP gene expression is a complex and important area of research, so I can understand your frustration in not finding much information on it. While a thermo unstable repressor mechanism is a possibility, there are also other regulatory mechanisms that have been identified. For example, heat shock transcription factors (HSFs) have been shown to play a major role in regulating HSP gene expression in response to stress. Additionally, epigenetic modifications, such as DNA methylation and histone acetylation, have also been found to influence HSP gene expression.

In terms of finding more information, I suggest looking into specific HSP gene families, such as HSP70 or HSP90, and their known regulatory mechanisms. You could also explore different stress conditions and how they affect HSP gene expression. Additionally, connecting with other researchers in this field or attending conferences on gene regulation may provide valuable insights and information.

Overall, it is clear that regulation of HSP gene expression is a complex and evolving area of research, and I wish you all the best in your exploration and discovery of this topic.