Health side effects caused by serotonin–dopamine-antagonist-antipsychotics

[lBrG]

It is known that serotonin–dopamine-antagonist-antipsychotics, among many other sideeffects, also commonly cause decrease of libido (for example https://www.drugs.com/sfx/quetiapine-side-effects.html, https://www.drugs.com/sfx/olanzapine-side-effects.html).

I know many cases where libido of many male patients has not recovered after years since ending treatment with antipsychotic drugs. In some cases it is excluded, that decrease of libido is caused by wrong concentration of testestorone, oestradiol, SHBG or prolactin in their blood (concentrations of these do not explain low libido).
How to explain these damages scientifically/medically(what and how it changed in their organism?)?

Is there any statistics available about such health damages caused by antipsychotic drugs?

 

[berkeman]

Welcome to PF.

It is known that serotonin–dopamine-antagonist-antipsychotics, among many other sideeffects, also commonly cause decrease of libido (for example https://www.drugs.com/sfx/quetiapine-side-effects.html, https://www.drugs.com/sfx/olanzapine-side-effects.html).

Your reference seems ambiguous on the effects on libido -- sometimes increased, sometimes decreased, usually with a small percentage of Pts affected in that way.

I know many cases where libido of many male patients has not recovered after years since ending treatment with antipsychotic drugs

Are these your Pts? Are you a physician?

How to explain these damages scientifically/medically(what and how it changed in their organism?)?

Can you find better scientific references than the one that you posted in order to support your assertion better? And perhaps some of those references will suggest the mechanisms for the effect, if it does exist?

 

[Godot_]

As you are apparently afraid of that side effect, you should talk to your doctor. Even the very best medication only works when it's actually taken, so you should mention that this fear might keep you from taking it.

 

[lBrG]

Your reference seems ambiguous on the effects on libido -- sometimes increased, sometimes decreased, usually with a small percentage of Pts affected in that way.

I know for sure that serotonin–dopamine-antagonist-antipsychotics have caused these health-damages (including erectile dysfunction) to multiple patients. And that these damages remain for years after using serotonin–dopamine-antagonist-antipsychotics. And that in some cases concentrations of hormones (testestorone, oestradiol, SHBG, prolactin and moany others) of blood of these patients are normal.
Could you give me any information about what kind of damages these are(what part of organism these affected) and how to cure these?
Where could I find information about it?

 

[BillTre]

From a a theoretical point of view,
you are dealing with a behavior which is generated by the functioning of the nervous system. There are many ways that changes in nervous system function could result in (in theory) changes in behavior.
For example, you are talking about levels of signalling molecules, but there are plenty of other parts of the overall system that could be changed in response to some strong shock condition (levels of receptors on target cells, cells dying, promoting gene expression, ...). Its not unreasonable to think that you could throw the system into a different mode of functioning, which may or may not need another shock or some other treatment to revert to it sold behavior. Life is complex and things like this (brain functioning and behavior) are one of the more complex things that there is.

From a more practical perspective,
if you really want an answer more in sync with medical reality, you would have to talk with medical or research people who specialize in these kind of things.

 

[lBrG]

Thank you for your response, @BillTre .

there are plenty of other parts of the overall system that could be changed in response to some strong shock condition (levels of receptors on target cells, cells dying, promoting gene expression, ...). Its not unreasonable to think that you could throw the system into a different mode of functioning, which may or may not need another shock or some other treatment to revert to it sold behavior.

What could the change be more specifically?

From a more practical perspective,
if you really want an answer more in sync with medical reality, you would have to talk with medical or research people who specialize in these kind of things.

Any advises how to find them and contact them?

 

[BillTre]

What could the change be more specifically?

There are many possibilities. Details would be needed to narrow down the list.

Any advises how to find them and contact them?

Talk to your doctor?
Search for publications on the specific subject.
Search for societies or organizations that would cover those issues.

 

[Tom.G]

Try these searches of government and research sites:

https://www.google.com/search?&q=quetiapine+side+effects+site:gov
https://scholar.google.com/search?&q=quetiapine+side+effects

 

[lBrG]

There are many possibilities. Details would be needed to narrow down the list.

The symptoms appeared in days after administrng antipsyhootic drugs and last for years after ending the use of antipsychotics.

FDG-PET(Fluorodeoxyglucose positron emission tomography): Does not hint to degenrative brain-desease. Parietal lobe:(D 0.97,S 1.03); Temporal lobe:(D0.51; S 1.28); Frontal lobe:(D 0.44; S 0.61); cingulate cortex: (D 0.35; S 0.47) Occipital lobe:(D 1.19; S 1.26) Nucles Caudatus:(D 1,89; S1,18)

EEG(Electroencephalography): everything normal. 9 up to 10 Hrz alpha-rythm in backside and center.

MRI(Magnetic resonance imaging): everyhing normal.

oestradiol <88.0 pmol/l
Prolactin: 172*mIU/l
Testosterone :40.2*nmol/l
SHBG:57*nmol/l
free Testosterone 107.0 pmol/l
Dihydrotestosterone 1.80 nmol/l
ACTH: 9.21*pmol/l
pregnenolone:3.16*nmol/l
androstenedione:4.12*nmol/l

DHEAS25.640 µmol/L

IGF-1: 134*ng/ml): everyhing normal.

oestradiol <88.0 pmol/l
Prolactin: 172*mIU/l
Testosterone :40.2*nmol/l
SHBG:57*nmol/l
free Testosterone 107.0 pmol/l
Dihydrotestosterone 1.80 nmol/l
ACTH: 9.21*pmol/l
pregnenolone:3.16*nmol/l
androstenedione:4.12*nmol/l

DHEAS25.640 µmol/L

IGF-1: 134*ng/ml

 

[berkeman]

Thread closed temporarily for Moderation...

 

[berkeman]

Thread is reopened with a reminder to the OP and responders that we cannot give medical advice here at PF. We can discuss the scientific literature, but that's as far as we can go. Thank you.