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Raghav Gupta
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By which reagent we would get 2-bromoacetophenone in one step from bromobenzene?
But that will give 2-bromo toluene or 4-bromotoluene.AdityaDev said:I'm sorry, I gave the answer for bromobenzene from 2-bromoacetophenone.
For the conversion, the answer is CH3Cl in anhydrous AlCl3 (acylation)
No. I am talking about acylation. It will give the required product. Check NCERT book.Raghav Gupta said:But that will give 2-bromo toluene or 4-bromotoluene.
I'm asking 2-bromoacetophenone from bromobenzene.
See structure of 2-bromoacetophenone.
As TeethWhitener said it will give acetyl group in the para position of bromobenzene.AdityaDev said:No. I am talking about acylation. It will give the required product. Check NCERT book.
Raghav, my teacher said, that the link thing is wrong, 2-bromoacetophenone is bromine attached at ortho position on the benzene ring. the compound in the link isRaghav Gupta said:See again the structure in the link given above in post.
Ya, I think you are right. Don't know why the wikipedia a famous site was showing that.Suraj M said:Raghav, my teacher said, that the link thing is wrong, 2-bromoacetophenone is bromine attached at ortho position on the benzene ring. the compound in the link is
1-phenyl-2-bromoethanone because acetophenone is nothing but 1-phenylethanone.
Easy.TeethWhitener said:Bromine is ortho-para directing, so Friedel-Crafts will give you a mixture of ortho and para isomers. Bonus question: how would you get meta-bromoacetophenone (starting from benzene)?
We'll probably get the thread locked for being off-topic, but it's fun regardless. Friedel-Crafts alkylation of benzene with a methyl halide to get toluene, then oxidize with permanganate to benzoic acid (now it's meta-directing), then repeat the process to get the 1,3-dicarboxyl compound.AdityaDev said:this conversion is even better: benzene to benzene-(1,3)-dicarboxylic acid. Try it.
But para one would be in majority because of steric hindrance by ortho group.TeethWhitener said:Bromine is ortho-para directing, so Friedel-Crafts will give you a mixture of ortho and para isomers.
Correct. It is interesting indeed.TeethWhitener said:We'll probably get the thread locked for being off-topic, but it's fun regardless. Friedel-Crafts alkylation of benzene with a methyl halide to get toluene, then oxidize with permanganate to benzoic acid (now it's meta-directing), then repeat the process to get the 1,3-dicarboxyl compound.
A reagent is a substance or compound that is used to cause or promote a specific chemical reaction. It is typically added in small amounts to a reaction mixture and is consumed during the reaction.
Bromobenzene is a compound with the chemical formula C6H5Br. It is a colorless liquid that is commonly used as a solvent in organic chemistry reactions. It is also used in the production of pharmaceuticals, pesticides, and other chemicals.
Reagent on bromobenzene, also known as bromobenzene Grignard reagent, is used in organic synthesis as a nucleophilic source of the benzene ring. It is formed by reacting bromobenzene with magnesium in the presence of an ether solvent. This reagent is commonly used in the synthesis of various organic compounds, such as alcohols, ketones, and carboxylic acids.
Reagent on bromobenzene is a flammable and toxic compound. It should be handled in a well-ventilated fume hood, and appropriate personal protective equipment, such as gloves and safety glasses, should be worn. It should also be stored in a tightly sealed container away from heat and sources of ignition.
Yes, reagent on bromobenzene can be substituted with other Grignard reagents or nucleophilic sources of the benzene ring in a chemical reaction. However, the specific properties and reactivity of bromobenzene may make it the most suitable choice for certain reactions. It is important to carefully consider the reaction conditions and desired products before substituting this reagent.