How is let-7 related to miR-98?

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In summary, the conversation discusses the website TargetScan, which is a database and tool for discovering miRNA-target gene interactions. The person has questions about the results obtained when searching for the gene Hmga2 in TargetScanMouse and why certain miRNAs are mentioned together. It is explained that these miRNAs are part of a family and all target similar sequences. The person also asks about multiple miRNAs being written together and it is clarified that they are synonyms and often target the same genes. Overall, the conversation highlights the use of TargetScan for studying miRNA interactions and the concept of miRNA families.
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TytoAlba95
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Hi. I have been recently introduced to a website called targetscan which is both a database and a tool to discover recorded miRNA-target gene interactions.
I'm stuck with some questions.
For TargetScanMouse, when Hmga2 gene is used as the query/input, a number of miRNAs come out. If I choose let-7 from this link it can be seen that let-7/miR-98 have been mentioned together. Why are they together? let-7 is a microRNA precursor, so is miR-98 its product miRNA?
Also multiple miRNAs are written together, for e.g. miR-15-5p/16-5p/195-5p/322-5p/497-5p, displayed at the middle bottom. Are they synonyms?
 
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let-7/miR-98 does not refer to a single miRNA, but a family of related miRNAs that all target similar sequences:
1604636081951.png

https://www.sciencedirect.com/science/article/pii/S0962892408002109

Other miRNAs are also part of miRNA families that target similar sequences, so they will often be identified together as targeting the same sets of genes.
 
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FAQ: How is let-7 related to miR-98?

1. How does let-7 regulate miR-98 expression?

Let-7 is a microRNA that plays a role in regulating gene expression. It has been found to directly target and suppress the expression of miR-98, leading to a decrease in its levels.

2. What is the function of miR-98 in relation to let-7?

MiR-98 is a microRNA that has been found to be regulated by let-7. It has been shown to play a role in various cellular processes, including cell proliferation, differentiation, and apoptosis.

3. Are there any other microRNAs that are regulated by let-7?

Yes, let-7 has been found to regulate the expression of multiple microRNAs, including miR-21, miR-200, and miR-34. These microRNAs have been shown to play important roles in various biological processes.

4. How is the let-7/miR-98 axis involved in cancer?

The let-7/miR-98 axis has been found to be dysregulated in various types of cancer. Let-7 has been shown to act as a tumor suppressor by targeting and suppressing the expression of oncogenes, including miR-98. Dysregulation of this axis can contribute to the development and progression of cancer.

5. Can targeting let-7 or miR-98 be used as a therapeutic approach?

Targeting let-7 or miR-98 has been explored as a potential therapeutic approach for various diseases, including cancer. However, more research is needed to fully understand the role of these microRNAs and their potential as therapeutic targets.

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