Ketosis/Ketoacidosis Reaction Mechanism?

[alkaseltzer]

I'm in a first year organic chemistry class with a biochem focus and I am going to do a project on ketoacidosis. While I can find the pathway online, since this is an organic chemistry class, I figure that a reaction mechanism that illustrates electron movement (arrows and such) would be preferred.

Do you know of any organic chemistry textbooks that have the reaction mechanism? A websource would be fine also, but I would prefer a textbook to cite.

Textbooks I have looked through which don't have the full mechanism with electron movement:
McMurry's The Organic Chemistry of Biological Pathways and Stryer's Biochemistry.

Also, general question on ketoacidosis...I know it can be caused by diabetes, alcoholism, starvation, and no carb diets, but is it the same mechanism. Also what is the difference between Ketosis and Ketoacidosis? From what I gather from what I read, Ketoacidosis is a more sever type of ketosis as the acidity from the keto-acids decreases the pH of the blood, while Ketosis merely means a to have a high level of ketones

 

[Nino MMP]

in the blood, but does not necessarily mean a low pH (acidic). A good textbook to help you find the reaction mechanism you are looking for is Organic Chemistry by Clayden, Greeves, Warren, and Wothers. This book provides detailed explanations of mechanisms with arrows and other illustrations. It also includes a section on biochemistry, which may be particularly useful for your project. Ketoacidosis and ketosis are related, but they are two different metabolic states. Ketoacidosis occurs when there is an accumulation of ketones in the bloodstream due to a lack of insulin or an inability to process carbohydrates properly. The body then begins to break down fatty acids and produce ketones as an alternative source of energy. These ketones increase the acidity of the blood, leading to a decrease in the pH and causing ketoacidosis. Ketosis is a metabolic state in which the body has elevated levels of ketones in the blood without a decrease in the pH. This can be caused by low-carbohydrate diets, fasting, or excessive exercise.