Male pheromones skew lab results

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In summary, a recent study published in Nature Methods found that the smell of male pheromones can cause a stress response in rodents equivalent to being confined or swimming. This suggests that the gender of the researcher may impact the results of animal studies. The lead researcher suggests that this factor should be stated in the methods sections of published papers to improve the replication of results. The study also found that male and female hormones can produce different responses in rodents, raising questions about establishing a neutral baseline in studies conducted by researchers of different genders.
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A first time study,

According to a study, published Monday in the journal Nature Methods by researchers from McGill University in Montreal, the distinct smell of male pheromones triggers a stress response in rodents equivalent to confining them in a tube for 15 minutes or making them swim for three minutes. Researchers say this is the first time a study has demonstrated lab rodents’ awareness of their human handlers.

has implications for duplication of experimetal animal studies,
"Our findings suggest that one major reason for lack of replication of animal studies is the gender of the experimenter -- a factor that's not currently stated in the methods sections of published papers," lead researcher Robert Sorge, a psychology professor at the University of Alabama and a postdoctoral fellow at McGill, said in a statement.

http://www.ibtimes.com/mice-men-lab...chers-might-affect-experiment-results-1577431
 
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Here's the original study:

Sorge et al. 2014 Olfactory exposure to males, including men, causes stress and related analgesia in rodents. Nature Methods. Published online 28 April 2014 http://dx.doi.org/10.1038/nmeth.2935

Abstract:
We found that exposure of mice and rats to male but not female experimenters produces pain inhibition. Male-related stimuli induced a robust physiological stress response that results in stress-induced analgesia. This effect could be replicated with T-shirts worn by men, bedding material from gonadally intact and unfamiliar male mammals, and presentation of compounds secreted from the human axilla. Experimenter sex can thus affect apparent baseline responses in behavioral testing.
 
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Male hormone exposure produces a guarded anxious response.
Female hormone exposure produces a calming response.

Since researchers are either male or female, how can a neutral baseline be established ( for any and all studies )?
 

FAQ: Male pheromones skew lab results

What are male pheromones?

Male pheromones are chemical substances secreted by males that can affect the behavior or physiology of other individuals, typically of the same species.

How do male pheromones skew lab results?

Male pheromones can skew lab results by altering the behavior or physiology of the subjects being studied. This can make it difficult to accurately measure the effects of other variables being tested.

Can male pheromones be controlled for in lab experiments?

Yes, male pheromones can be controlled for in lab experiments by using only female subjects or by using synthetic pheromones that do not affect the behavior of the subjects.

Are male pheromones always present in lab settings?

No, male pheromones are not always present in lab settings. They may be absent if the subjects are all female or if the lab environment is controlled to prevent the release of pheromones.

How can researchers account for male pheromones in their studies?

Researchers can account for male pheromones in their studies by using control groups, using synthetic pheromones, or conducting experiments in a controlled environment where pheromone release is prevented.

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