To simplify the integral ∫cos^5(x)dx, it is recommended to factor out one cosine term when dealing with sine or cosine raised to an odd power. This allows for the substitution of u = sin(x), transforming the integral into a more manageable form. The expression can be rewritten as (cos^4(x))(cos(x)dx), which further simplifies to (1 - sin^2(x))^2(cos(x)dx). This method effectively reduces the complexity of the integral. Mastering these trigonometric substitutions can significantly ease the process of integration.