Mitochondrial Mutation & Increased State 4 Respiration

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In summary, the conversation discussed a patient with a mitochondrial mutation causing lethargy. A subsequent test revealed increased state 4 respiration but normal state 3 respiration. The speaker proposed that the mutation may have increased leak across the inner mitochondrial membrane, activating the respiratory chain. However, the answer to the question provided an ADP addition experiment which the speaker did not understand.
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nokia8650
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i was undertaking a question regarding a patient who had a mutation in their mitochondria, and hence experienced lethargy. A subsequent test of his mitochondria found his mitochondria to have an increased state 4 respiration, but a normal state 3 respiration.

In order to explain this, I would have thought that perhaps some mutation has results in increased leak across the inner mitochondrial membrane, dissipating the PMF and thus electric field across the membrane, in turn activating the respiratory chain. However, the answer for the question was:

http://img94.imageshack.us/img94/9099/screenshot20100411at184.png

Can someone explain this answer to me; i am unable to understand it; and what is wrong with my explanation?

Thank you!
 
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It would help if you copied the entire question. I don't understand the ADP addition experiment from what you copied alone.
 

FAQ: Mitochondrial Mutation & Increased State 4 Respiration

What is a mitochondrial mutation?

A mitochondrial mutation is a change in the genetic material of the mitochondria, which are organelles found in cells that are responsible for producing energy. These mutations can result in a variety of health issues, including increased state 4 respiration.

How does a mitochondrial mutation affect state 4 respiration?

A mitochondrial mutation can lead to an increase in state 4 respiration, which is the rate at which cells use oxygen to produce energy. This can result in a decrease in overall energy production and can lead to various health problems.

3. What are the symptoms of a mitochondrial mutation?

The symptoms of a mitochondrial mutation can vary depending on the specific mutation and its severity. However, some common symptoms include muscle weakness, fatigue, developmental delays, and neurological issues.

4. Is a mitochondrial mutation hereditary?

Yes, mitochondrial mutations can be hereditary, meaning they are passed down from a parent to their child. This is because mitochondria contain their own genetic material, separate from the DNA found in the nucleus of cells.

5. Can a mitochondrial mutation be treated?

Currently, there is no cure for mitochondrial mutations. However, there are treatments available to manage symptoms and improve quality of life. These can include medications, supplements, and lifestyle changes such as a healthy diet and regular exercise.

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