The discussion centers on whether every smooth n-manifold can be embedded in R^(2n+1) to coincide with an affine variety over R. It highlights a significant theorem regarding the embedding of manifolds and the implications of the Zariski topology, noting that since R is not finite, embedded manifolds are Hausdorff, preventing identification with affine varieties as submanifolds of R^N. The conversation references GAGA-style results, which connect manifolds to affine varieties, emphasizing the correspondence between Hausdorff and separated varieties, as well as compact and complete varieties. A recommendation is made for the book "Algebraic and Analytic Geometry" by Neeman for further exploration of these concepts. The discussion concludes with a suggestion to investigate theorems and conjectures by Nash and Kollár for deeper insights.