Structural Questions about Memory B cells

AI Thread Summary
The discussion centers on B cells, specifically their structural differences and detection methods. Key points include the differentiation of naive B cells, activated B cells, plasma B cells, and memory B cells, with a focus on comparing plasma and memory B cells. The conversation highlights the importance of understanding these structural variations for immunological studies. Additionally, it addresses the feasibility of detecting and measuring these cell types, particularly plasma and memory B cells in relation to specific antigens. Recommendations for resources include accessing immunology textbooks such as "Roitt's Essential Immunology" and "Janeway's Immunobiology," as well as exploring free online courses to deepen knowledge in immunology. The discussion suggests that a comprehensive understanding is essential, cautioning against superficial overviews that may lead to confusion.
mktsgm
Messages
151
Reaction score
22
TL;DR Summary
Is there a structural difference between mature B cells and memory B cells?
I have the following doubts regarding B cells.

Normally upon the stimulation by a T-cell, the activated B-cell differentiates into plasma and memory cells.

1) What are the structural differences among the naive B-cells, activated B-cells, Plasma B-cells, and memory B-cells? I am interested in the comparison of structures of Plasma B-cells and memory B-cells.
2) Is it possible to detect and measure all four?
a) Again I am particularly interested in the Plasma B-cells and memory B-cells for a particular antigen. How do we differentiate between them and can we detect and measure them?

Thanks in advance,
 
  • Like
Likes atyy
Biology news on Phys.org
This would require about 40 pages on the forum.

https://www.academia.edu/40521511/Janeways_Immunobiology_9th_Edition
Janeway Immunobiology 9th ed is in the public domain. Please download the and start reading with the caveat that more details about some more aspects of antibody creation are now known.

If there is acopy of the current 10th edition in a local school library, try that.

Actually the best thing you could do (if you have enough background) is to take a look at courses offered free over the internet. Start with into Virology, then go from there.

What you need is not feasible for PF. And a marginal overview will confuse you unduly.

That's all for now.
 
I've been reading a bunch of articles in this month's Scientific American on Alzheimer's and ran across this article in a web feed that I subscribe to. The SA articles that I've read so far have touched on issues with the blood-brain barrier but this appears to be a novel approach to the problem - fix the exit ramp and the brain clears out the plaques. https://www.sciencealert.com/new-alzheimers-treatment-clears-plaques-from-brains-of-mice-within-hours The original paper: Rapid amyloid-β...
https://www.discovermagazine.com/the-deadliest-spider-in-the-world-ends-lives-in-hours-but-its-venom-may-inspire-medical-miracles-48107 https://en.wikipedia.org/wiki/Versutoxin#Mechanism_behind_Neurotoxic_Properties https://www.sciencedirect.com/science/article/abs/pii/S0028390817301557 (subscription or purchase requred) The structure of versutoxin (δ-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel...

Similar threads

Back
Top