What are the underlying principles of hydrophobicity at the molecular level?

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In summary, the conversation discusses the search for a good reference on the physics of hydrophobicity at a molecular level, specifically focusing on amino acids. The speaker mentions that the wiki articles are not sufficient and asks for any other resources. Another participant suggests an article which explains that hydrophobic interactions are primarily driven by entropic processes. However, the speaker would like to find a more detailed and statistical mechanics-based discussion on the topic.
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dipole
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Hi, I'm looking for a good reference on the physics of hydrophobicity on the level of molecules. I'm specifically interested in amino acids, but I'd prefer a more general discussion.

The wiki articles are pretty slim, so hoping someone here might have a better resource. Thanks.
 
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I'm sorry you are not generating any responses at the moment. Is there any additional information you can share with us? Any new findings?
 
  • #3
I found this article cited by the wiki: http://pubs.acs.org/doi/abs/10.1021/ed075p116

which has a reference to this one: http://pubs.acs.org/doi/pdf/10.1021/ed066p581

The basic message I took from the above is that hydrophobic interactions are mostly driven by entropic processes - i.e. the "TΔS" term in the Gibbs free energy. I stopped at this point, but it would be cool to see a more in-depth discussion, and one which is written perhaps from a more statistical mechanics point of view rather than just pure thermodynamics and some handwaving.
 

FAQ: What are the underlying principles of hydrophobicity at the molecular level?

What is hydrophobicity?

Hydrophobicity refers to the physical property of a substance that repels or does not mix well with water. This can be due to the molecular structure of the substance, which makes it difficult for water molecules to interact with it.

How is hydrophobicity measured?

The degree of hydrophobicity is measured using a scale called the contact angle. This is the angle formed between a water droplet and the surface of the substance. The higher the contact angle, the more hydrophobic the substance is.

What causes hydrophobicity?

Hydrophobicity is mainly caused by the presence of nonpolar molecules or functional groups in a substance. These molecules or groups do not have a charge and are therefore not attracted to water molecules, resulting in repulsion.

What are some examples of hydrophobic substances?

Examples of hydrophobic substances include oils, fats, waxes, and many organic compounds such as plastics. These substances are often used as waterproofing agents in various products due to their hydrophobic nature.

How does hydrophobicity affect living organisms?

Hydrophobicity plays an important role in many biological processes, such as the formation of cell membranes and the folding of proteins. It also helps organisms, such as plants, to retain water and avoid dehydration in dry environments. In some cases, hydrophobicity can also have negative effects, such as in the case of water pollution caused by hydrophobic chemicals.

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