What's the Difference Between Enhancer Fusion and Promoter Fusion?

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In summary, a fusion refers to combining two or more DNA sequences together. If one of the sequences is an enhancer, the resulting fusion is called an enhancer fusion. Similarly, a promoter fusion is created when one of the sequences is a promoter. It is also possible to have a promoter-enhancer fusion. However, there is no clear distinction between promoters and enhancers.
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Also how is it different (if at all) from promoter fusion?
 
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Fusion just means you make a single DNA sequence by joining 2 or more other sequences. If one of the sequences is an enhancer, then the resulting joined sequence is an enhancer fusion. If one of the sequences is a promoter, then the resulting joined sequence is a promoter-fusion. You can, of course, get promoter-enhancer fusions, eg. "The process was analysed in transgenic flies carrying beta 1 enhancer-hsp70 promoter-lacZ fusion constructs."

There isn't a strict distinction between promoters and enhancers.
http://www.ncbi.nlm.nih.gov/books/NBK21745/#A2566
 
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Thanks a bunch.
 

FAQ: What's the Difference Between Enhancer Fusion and Promoter Fusion?

What is enhancer fusion?

Enhancer fusion is a process where two or more enhancer sequences are combined to form a single, larger enhancer sequence. Enhancers are short stretches of DNA that can increase the transcription of nearby genes.

Why is enhancer fusion important?

Enhancer fusion can lead to changes in gene expression, which can impact the development and function of an organism. It can also be used in biotechnology and genetic engineering to control gene expression and potentially treat diseases.

How is enhancer fusion different from gene fusion?

Enhancer fusion involves the combination of enhancer sequences, while gene fusion involves the fusion of two or more genes. Enhancer fusion can impact the expression of genes, while gene fusion can affect the structure and function of proteins produced by those genes.

What are the potential consequences of enhancer fusion?

Enhancer fusion can lead to changes in gene expression, which can result in altered cellular processes and potentially lead to disease. It can also influence the development and function of an organism.

Can enhancer fusion occur naturally?

Yes, enhancer fusion can occur naturally through genetic mutations or rearrangements in the genome. It can also be intentionally induced through biotechnology and genetic engineering techniques.

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