- #1
rall1959
- 3
- 2
- How did you find PF?
- Via Google Gemini and general search
Hello,
my name is Bruno and I am a biochemist with a masters in medical biochemistry, currently finishing a PhD in neuroscience.
Researchers have been using mathematical models to describe the world for a long time (basically all physical laws, etc.). While physicists and mathematicians are generally ok with this, biologists and medical doctors don't look at computational renderings of biological material with a peaceful mood. Thus, most of my references within the neurosciences are behavioural (lent by psychology) and biochemical, and until recently I barely had any contact with neuronal modelling (other than, e.g., the standard equations defining ionic equilibria (Nernst equation) or membrane equilibria (GHK equation)).
Eventually I came across the work of Wilfrid Rall (1922-2018) through a book collection of his most important papers (ed. Idan Segev et al., 1994) and started delving into computational neuroscience (namely the importance of dendrites) on my spare time. I created an account at the Physics Forums website in order to place a question regarding solutions to the passive cable equation, in trying to make sense of the excellent book by Daniel Johnston & Samuel Wu, Foundations of Cellular Neurophysiology (1994).
My work has been mostly on synaptic channel receptors of the AMPA type and their importance for memory expression. In the future, I intend to further understand what happens to the currents and membrane voltages generated by AMPARs, between the synapse and the dendrite (still much controversial, given the unsolved spine neck resistance problem), and then between the dendrite and the soma.
[Mentor Note: whitespace and paragraphs added for readability]
my name is Bruno and I am a biochemist with a masters in medical biochemistry, currently finishing a PhD in neuroscience.
Researchers have been using mathematical models to describe the world for a long time (basically all physical laws, etc.). While physicists and mathematicians are generally ok with this, biologists and medical doctors don't look at computational renderings of biological material with a peaceful mood. Thus, most of my references within the neurosciences are behavioural (lent by psychology) and biochemical, and until recently I barely had any contact with neuronal modelling (other than, e.g., the standard equations defining ionic equilibria (Nernst equation) or membrane equilibria (GHK equation)).
Eventually I came across the work of Wilfrid Rall (1922-2018) through a book collection of his most important papers (ed. Idan Segev et al., 1994) and started delving into computational neuroscience (namely the importance of dendrites) on my spare time. I created an account at the Physics Forums website in order to place a question regarding solutions to the passive cable equation, in trying to make sense of the excellent book by Daniel Johnston & Samuel Wu, Foundations of Cellular Neurophysiology (1994).
My work has been mostly on synaptic channel receptors of the AMPA type and their importance for memory expression. In the future, I intend to further understand what happens to the currents and membrane voltages generated by AMPARs, between the synapse and the dendrite (still much controversial, given the unsolved spine neck resistance problem), and then between the dendrite and the soma.
[Mentor Note: whitespace and paragraphs added for readability]
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