How much energy does annihilation take?

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Mixing matter with antimatter leads to annihilation, which releases energy according to the equation E=mc², but does not require energy to initiate the mixing. The challenge lies not in bringing matter and antimatter together, but in preventing them from coming into contact, as they will naturally attract due to opposite charges. To keep antimatter isolated from matter, energy is needed to create containment systems, such as magnetic bottles. These systems are essential to prevent spontaneous annihilation upon contact. Thus, while annihilation itself releases energy, significant energy is required to maintain the separation of matter and antimatter.
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Many people say that when mixing matter with anti-matter , energy is released according to e=mc2 however how much energy does it take to mix matter with antimatter which leads to annihilation .
 
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It does not require energy. In the case of charged particles, they even attract each other as they have opposite charge.
 
The problem with matter and antimatter is not the amount of energy you need to expend to get them to come together - the problem is the amount of energy you need to expend to get them to keep them apart.

Both matter and antimatter will happily float around and come into physical contact with each other (including the walls of the container or any air in it), whereupon annihilation will occur spontaneously. To stop this from happening the moment you create any amount of anti-matter, you must devise a way of keeping it away from matter. This is usually done with magnetic bottles. Which require energy.
 

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