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Ry122 said:interactions like Q-point and harmonics?
edit: nevermind, that's only for LC circuits. I'm not sure what interactions you mean then.
Interaction means: The 2nd passive stage must not load the 1st stage because this makes calculations much more complicated.
It is much better to design lowpass and highpass separately (indpendent on each other) and to combine them with a buffer in between.
Perhaps the finite input resistance of the buffer must be included in the design of the 1st stage (depends on the buffer realization).