Medical New Alzheimer's Treatment Clears Plaques From Brains of Mice Within Hours

[Borg]

I've been reading a bunch of articles in this month's Scientific American on Alzheimer's and ran across this article in a web feed that I subscribe to. The SA articles that I've read so far have touched on issues with the blood-brain barrier but this appears to be a novel approach to the problem - fix the exit ramp and the brain clears out the plaques.
https://www.sciencealert.com/new-alzheimers-treatment-clears-plaques-from-brains-of-mice-within-hours

The original paper:
Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport

 

[.Scott]

Assuming the mouse is a good model for humans, the very clear implication is that the amyloid deposits are likely normal and the failure of their routine removal is what's pathogenic.

 

[Dale]

Assuming the mouse is a good model for humans

The paper does look very promising. However, it is good to be mindful of the huge pile of promising treatments that have died on this assumption. That said, even if this specific intervention doesn’t pan out, the avenue that it has opened probably has other possibilities too.

 

[Borg]

The paper does look very promising. However, it is good to be mindful of the huge pile of promising treatments that have died on this assumption. That said, even if this specific intervention doesn’t pan out, the avenue that it has opened probably has other possibilities too.

Agree 100%. Even if it fast-tracked, it would be years before it becomes an available treatment. But, if it pans out, it would help millions beyond belief.

 

[jrmichler]

I have been collecting articles and papers on lifestyle vs health. Here's some about dementia:

Healthy lifestyle reduced risk of Alzheimer's by 60%: https://www.nih.gov/news-events/new...le-traits-may-substantially-reduce-alzheimers

Exercise produces hormone that protects against Alzheimer's:
Article: https://www.medicalnewstoday.com/ar...ngles-in-the-brain#The-importance-of-exercise
Paper: https://www.cell.com/neuron/fulltext/S0896-6273(23)00623-2

Active lifestyle halts memory loss: https://neurosciencenews.com/lifestyle-coach-alzheimers-25258/

Healthy lifestyle protects against dementia, even with beta-amyloid buildup
Article: https://www.cnn.com/2024/02/05/health/healthy-living-dementia-study-wellness/index.html
Paper: https://jamanetwork.com/journals/ja...ccessKey=cd485704-d985-4ea8-87ad-ee110ddaa953

Unfortunately, healthy lifestyle is not a patented drug with a high profit margin, so there is no well funded effort to sell it. But I can do my part. My morning run was 4.4 miles today.