The standard, in medical research especially, is to ask "Is there anything that substantiates this claim?"dsaun777 said:Can anyone refute the nmn research being done by him.
That is a cautionary indicator (orange/yellow flag).dsaun777 said:But the concentration of NMN in the supplements is many magnitudes higher than would be in any food.
https://www.hsph.harvard.edu/nutritionsource/niacin-vitamin-b3/Niacin, or vitamin B3, is a water-soluble B vitamin found naturally in some foods, added to foods, and sold as a supplement. The two most common forms of niacin in food and supplements are nicotinic acid and nicotinamide. The body can also convert tryptophan—an amino acid—to nicotinamide. Niacin is water-soluble so that excess amounts the body does not need are excreted in the urine. Niacin works in the body as a coenzyme, with more than 400 enzymes dependent on it for various reactions. Niacin helps to convert nutrients into energy, create cholesterol and fats, create and repair DNA, and exert antioxidant effects.
in the same article from the Mayo ClinicNiacin overdose is unlikely if you take niacin only in the amount prescribed by your doctor. While it's not possible to overdose on niacin simply by eating too many niacin-rich foods, taking too much over-the-counter or prescription niacin can be dangerous.
Because niacin [I believe this means excessive levels of] has also been linked to liver damage and strokes, most doctors now recommend it only for people who can't take statins to treat high triglyceride levels. If you're concerned about taking niacin, talk to your doctor.
Nicotinamide mononucleotide (NMN) is a molecule that is naturally produced in the body from Vitamin B3 (niacin). It plays a crucial role in various biological processes, including energy metabolism and DNA repair.
Some studies suggest that NMN supplementation may help improve cellular function, boost metabolism, and promote healthy aging. It may also have potential benefits for conditions such as diabetes, obesity, and neurodegenerative diseases, but more research is needed to confirm these effects.
NMN is a precursor to another molecule called nicotinamide adenine dinucleotide (NAD+), which is essential for cellular energy production. While other forms of Vitamin B3, such as niacin and nicotinamide, can also be converted into NAD+, NMN is believed to be a more direct and efficient way to increase NAD+ levels in the body.
NMN is generally considered safe and well-tolerated. However, some people may experience mild side effects such as nausea, diarrhea, or flushing. It is always recommended to consult with a healthcare professional before starting any new supplement.
The optimal dosage of NMN is still being studied, but most research suggests a range of 250-500 mg per day. It is important to note that the effects of NMN may vary depending on factors such as age, health status, and individual response. It is best to start with a lower dosage and gradually increase as needed, under the guidance of a healthcare professional.