SARS-CoV-2 Exposure without Infection

[morrobay]

TL;DR Summary

Close contact exposure to Sars-Cov-2 without infection.

From page 6: 'Close contacts who are Sars-Cov-2 exposed are often both NAT negative and antibody negative indicating that Sars-Cov-2 failed to establish a successful infection'. So the exposure generated memory T cells in absence of an infection. I wonder how quantitatively widespread in a population this would be ?https://www.researchgate.net/publication/350192067_Exposure_to_SARS-CoV-2_generates_T-cell_memory_in_the_absence_of_a_detectable_viral_infection

 

[morrobay]

Given that current efforts focus on vaccine mediated protection . This study highlights the need for a much more holistic approach to understand true immune response. Given that T and B cell longevity is greater that vaccine/antibody protection I am somewhat baffled as to why there has not been more effort in this area. https://www.covid19immunitytaskforc...unity-in-the-absence-of-detectable-infection/