For the case of equal mass scattering, one may derive in the centre of mass frame the following relations for the Mandelstam invariants ##s,t,u##:
$$s = 4(\mathbf p^2 + m^2) ,\,\,\,\,t=-2\mathbf p^2 (1- \cos \theta), \,\,\,\text{and} \,\,\,\,u = -2\mathbf p^2 (1+\cos \theta) $$ As the physical domain of the variables is such that ##\mathbf p^2 \geq 0## and ## -1 \leq \cos \theta \leq 1##, means that ##s \geq 4m^2, t \leq 0, u \leq 0## with the equalities holding when the relative momentum vector ##\mathbf p = 0##.
In particular, and coming to your question now, if ##s## is above threshold, meaning that ##s## is higher than the ##4m^2##, then ##u## and ##t## are strictly less than zero. This all collectively maintains the constraint ##s+t+u = 4m^2##. So, the ##t## and ##u## channel diagrams proportional to ##1/t## and ##1/u## respectively, at the amplitude level, do not admit singular structures as ##t## and ##u## may not be nullified when ##s## is above ##4m^2.##