What Factors Influence Our Ability to Change Gene Expression?

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What makes us able to change the expression of some genes and unable to change the expression of other genes?
 
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Thread 'New Alzheimer's Treatment Clears Plaques From Brains of Mice Within Hours'

I've been reading a bunch of articles in this month's Scientific American on Alzheimer's and ran across this article in a web feed that I subscribe to. The SA articles that I've read so far have touched on issues with the blood-brain barrier but this appears to be a novel approach to the problem - fix the exit ramp and the brain clears out the plaques. https://www.sciencealert.com/new-alzheimers-treatment-clears-plaques-from-brains-of-mice-within-hours The original paper: Rapid amyloid-β...
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